Cannabis sativa and its influence on the intelligence of its users
DOI:
https://doi.org/10.23882/rmd.22073Keywords:
Cannabis Sativa, Marijuana, Intelligence, memory strategies, Nervous SystemAbstract
Popularly known as marijuana, Cannabis sativa presents compounds that can be used as therapeutics and substances that affect the nervous system and, due to this fact, it is classified as an illegal drug. The main psychoactive substance in cannabis shows enormous influence on the brain, THC reaches the central nervous system, recognizes receptors in the area and binds, and this action is responsible for its effects. Thus, the aim of this study is to understand whether individuals who make recreational use of Cannabis sativa can be affected by decreased intelligence and, therefore, it starts from a literature review, carried out through the following databases: SciELO, PubMed PsycINFO and Science Direct. The chronic use of the substance is possible to develop some harmful effects on learning, attention, cognitive function and working memory and such effects together hinder the individual's learning.
References
Batalla, A.; Crippa, J.A.; Busatto, G.F.; Guimaraes, F.S.; Zuardi, A.W.; Valverde, O.; Atakan, Z.; McGuire, P.K.; Bhattacharyya, S.; Martín-Santos, R. (2014). Neuroimag-ing Studies of Acute Effects of THC and CBD in Humans and Animals: a Systematic Review. Current Pharmaceutical Design, 20(13). 2168-2185(18).
Bindesri, S. D., Jebailey, R., Albarghouthi, N., Pye, C. C., & Brosseau, C. L. (2020). Spectroelectrochemical and computational studies of tetrahydrocannabinol (THC) and carboxy-tetrahydrocannabinol (THC-COOH). Analyst, 145(5), 1849-1857. https://doi.org/10.1039/C9AN02173F
Block, R. I., O'Leary, D. S., Hichwa, R. D., Augustinack, J. C., Ponto, L. L. B., Ghoneim, M. M., ... & Andreasen, N. C. (2000). Cerebellar hypoactivity in frequent marijuana users. Neuroreport, 11(4), 749-753.
Castillo, P. E., Younts, T. J., Chávez, A. E., & Hashimotodani, Y. (2012). Endocanna-binoid signaling and synaptic function. Neuron, 76(1), 70-81. https://doi.org/10.1016/j.neuron.2012.09.020
Chang, L., Yakupov, R., Cloak, C., & Ernst, T. (2006). Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain, 129(5). 1096–1112. https://doi.org/10.1093/brain/awl064
Cohen, K., Weizman, A., & Weinstein, A. (2019). Positive and negative effects of cannabis and cannabinoids on health. Clinical Pharmacology & Therapeutics, 105(5), 1139-1147. https://doi.org/10.1002/cpt.1381
Corrêa, L. T., Plata, C. F., Ricci, E. L., Nicoletti, M. A., Caperuto, E. C., de Souza Spi-noza, H., ... & Fukushima, A. R. (2020). Revisão Bibliográfica Sistematica-Sistema de Endocanabinoides Tendências de Uso na Farmacologia. Brazilian Journal of Fo-rensic Sciences, Medical Law and Bioethics, 9(2), 146-167. https://doi.org/10.17063/bjfs9(2)y2020146
Decreto Nº 9.761, de 11 de Abril (2019). Aprova a Política Nacional sobre Drogas. Diário Oficial da União: Edição 70-A, Seção 1 Extra, Página 7. https://bit.ly/3l9gXZj
Devinsky, O., Cilio, M. R., Cross, H., Fernandez‐Ruiz, J., French, J., Hill, C., ... & Friedman, D. (2014). Cannabidiol: pharmacology and potential therapeutic role in ep-ilepsy and other neuropsychiatric disorders. Epilepsia, 55(6), 791-802. https://doi.org/10.1111/epi.12631
Dhadwal, G., & Kirchhof, M. G. (2018). The Risks and Benefits of Cannabis in the Dermatology Clinic. Journal of Cutaneous Medicine and Surgery, 22(2), 194–199. https://doi.org/10.1177/1203475417738971
Dinis-Oliveira, R. J. (2016). Metabolomics of Δ9-tetrahydrocannabinol: implications in toxicity. Drug metabolism reviews, 48(1), 80-87. https://doi.org/10.3109/03602532.2015.1137307
Djeungoue‐Petga, M. A., & Hebert‐Chatelain, E. (2017). Linking mitochondria and synaptic transmission: the CB1 receptor. Bioessays, 39(12), 1700126. https://doi.org/10.1002/bies.201700126
ElSohly, M. A., Radwan, M. M., Gul, W., Chandra, S., & Galal, A. (2017). Phytochemistry of Cannabis sativa L. Phytocannabinoids, 1-36. https://doi.org/10.1007/978-3-319-45541-9_1
Ferraro, L., Russo, M., O'Connor, J., Wiffen, B. D., Falcone, M. A., Sideli, L., ... & Di Forti, M. (2013). Cannabis users have higher premorbid IQ than other patients with first onset psychosis. Schizophrenia Research, 150(1), 129-135. https://doi.org/10.1016/j.schres.2013.07.046
Fogaça, J.R.V. (2020) THC - Principal componente ativo da maconha. Mundo Educação. https://bit.ly/3qszTFQ
Ford, T. C., Hayley, A. C., Downey, L. A., & Parrott, A. C. (2017). Cannabis: an over-view of its adverse acute and chronic effects and its implications. Current drug abuse reviews, 10(1), 6-18. https://doi.org/10.2174/1874473710666170712113042
Gibbons, C. H. (2019). Basics of autonomic nervous system function. Handbook of clinical neurology, 160, 407-418. https://doi.org/10.1016/B978-0-444-64032-1.00027-8
Grant, I., Gonzalez, R., Carey, C. L., Natarajan, L., & Wolfson, T. (2003). Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study. Journal of the International Neuropsychological Society, 9(5), 679-689. https://doi.org/10.1017/S1355617703950016
Hamilton, I., & Hugues, E. (2020, julho 16). Maconha faz mal – mas também faz bem – à memória. Projeto Colabora. https://bit.ly/3HagGhY
Heiss, C. N., & Olofsson, L. E. (2019). The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system. Journal of neuroendocrinology, 31(5), e12684. https://doi.org/10.1111/jne.12684
Lorenzetti, V., Solowij, N., Fornito, A., Ian Lubman, D., & Yucel, M. (2014). The asso-ciation between regular cannabis exposure and alterations of human brain morpholo-gy: an updated review of the literature. Current pharmaceutical design, 20(13), 2138-2167.
Lundqvist, T. (2005) Cognitive consequences of cannabis use: comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions. Pharmacol Biochem Behav. 81(2), 319-330 https://doi.org/10.1016/j.pbb.2005.02.017
Martín-Santos, R., Fagundo, A., Crippa, J., Atakan, Z., Bhattacharyya, S., Allen, P., . . . McGuire, P. (2010). Neuroimaging in cannabis use: A systematic review of the litera-ture. Psychological Medicine, 40(3), 383-398. https://doi.org/10.1017/S0033291709990729
Miettunen, J., Törmänen, S., Murray, G., Jones, P., Mäki, P., Ebeling, H., . . . Veijola, J. (2008). Association of cannabis use with prodromal symptoms of psychosis in ado-lescence. British Journal of Psychiatry, 192(6), 470-471. https://doi.org/10.1192/bjp.bp.107.045740
Nestler, E. J.; Hyman S. E.; Robert, C. M. (2001). Molecular neuropharmacology: a foundation for clinical neuroscience. New York: McGraw-Hill. 539p.
Paronis, C. A., Nikas, S. P., Shukla, V. G., & Makriyannis, A. (2012). Δ9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice. Behavioural pharmacology, 23(8), 802. https://doi.org/10.1097%2FFBP.0b013e32835a7c4d
Radhakrishnan, R., Wilkinson, S. T., & D’Souza, D. C. (2014). Gone to pot–a review of the association between cannabis and psychosis. Frontiers in psychiatry, 5, 54. https://doi.org/10.3389/fpsyt.2014.00054
Ribeiro, J. A. C. (2015). A cannabis e suas aplicações terapêuticas. Tese de Doutorado. Universidade Fernando Pessoa. http://hdl.handle.net/10284/4828
Robinson, T. E., & Becker, J. B. (1986). Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain research reviews, 11(2), 157-198. https://doi.org/10.1016/0165-0173(86)90002-0
Schreiner, A. M., & Dunn, M. E. (2012). Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis. Experimental and clinical psychopharmacology, 20(5), 420–429. https://doi.org/10.1037/a0029117
Schweinsburg, A. D., Nagel, B. J., Schweinsburg, B. C., Park, A., Theilmann, R. J., & Tapert, S. F. (2008). Abstinent adolescent marijuana users show altered fMRI response during spatial working memory. Psychiatry Research: Neuroimaging, 163(1), 40-51. https://doi.org/10.1016/j.pscychresns.2007.04.018
Volkow, N. D., Baler, R. D., Compton, W. M., & Weiss, S. R. (2014). Adverse health effects of marijuana use. New England Journal of Medicine, 370(23), 2219-2227. https://doi.org/10.1056/NEJMra1402309
Wilson, W., Mathew, R., Turkington, T., Hawk, T., Coleman, R. E., & Provenzale, J. (2000). Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study. Journal of addictive diseases, 19(1), 1-22. https://doi.org/10.1300/J069v19n01_01
Yücel, M., Solowij, N., Respondek, C., Whittle, S., Fornito, A., Pantelis, C., & Lub-man, D. I. (2008). Regional brain abnormalities associated with long-term heavy cannabis use. Archives of general psychiatry, 65(6), 694-701. https://doi.org/10.1001/archpsyc.65.6.694
Zalesky, A., Solowij, N., Yücel, M., Lubman, D. I., Takagi, M., Harding, I. H., ... & Seal, M. (2012). Effect of long-term cannabis use on axonal fibre connectivity. Brain, 135(7), 2245-2255. https://doi.org/10.1093/brain/aws136
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